When we talk about Lion’s Mane, we’re not talking about the fluffy white mushroom itself or the dried yellowy powder—we’re talking about the compounds it contains. The bioactives. The reason you’re taking it in the first place, right?
Here’s a quick refresher:
Lion’s Mane contains a variety of molecules that interact with the body in targeted, powerful ways. Among the most studied are hericenones and erinacines—compounds that stimulate nerve growth factor (NGF), which is crucial for neuron repair, regeneration, and brain plasticity. These are the compounds that make Lion’s Mane a standout in the world of natural nootropics.
There are also beta-glucans, which support immune function, and antioxidant molecules that protect cells from damage. Each of these compounds has a different solubility, sensitivity to heat, and absorption behaviour inside the body.
You may be thinking that you get these compounds automatically when you eat or take Lion's Mane. That's actually a common misconception, and fair enough because the mushroom industry is largely unregulated so companies might list how much mushroom starting weight goes into the product but they definitely don't have a "nutrition facts" style of label actually listing the milligrams of active compounds you're getting. How the mushroom is grown to how it is processed actually determines the milligrams of bioactive compound content and so most of these products would have a very empty content label!
The best analogy I can think of is coffee. You know the word "coffee" isn' all encompassing, and coffee is absolutely not all the same everywhere and in every form. Australia has a fantastic coffee culture. They know the difference between a good coffee and a bad one, the quality difference between the big freeze dried tin on the bottom shelf to a carefully crafted fragrant roast, and most importantly the difference between decaf and regular. I would go so far as to say that when you go to a cafe you don't order "coffee" and are ok with whatever they put in front of you, like it's a lucky dip, especially if there was a very high chance you'd get a decaf to start the day! I think it's safe to say nobody would pay today's coffee prices for a of a cup that probably doesn't even contain caffeine. We all know that caffeine is the active compound in coffee that boosts energy, and we all drink coffee in the morning to wake up right? So what would be the point of paying expensive prices for a who knows what average coffee that probably doesn't have caffeine in it. In Australia? Blasphemous.
So just like "coffee" is not "coffee" (there's widely varying quality and even decaf to watch out for!) "Lion's Mane" is not "Lion's Mane" when it comes to mushroom supplements.
Just like caffeine and the brew is to coffee, the bioactives and the extraction are to mushroom products.
So it’s not about how much mushroom starting material you have, it's actually about whether the compounds that matter are even present and if the extraction was good enough to get them into your cup.